Ushbu fayl Vikiomborga yuklangan boʻlib, boshqa loyihalarda ham qoʻllanilishi mumkin.
Uning tavsif sahifasidan olingan maʼlumot quyida keltirilgan.
Qisqa izoh
TaʼrifHIF Nobel Prize Physiology Medicine 2019 Hegasy ENG.png
English: Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability.
Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. The protein then associates with VHL and is subsequently tagged with ubiquitin. Tagged Hif-1 alpha is then translocated to the proteasome, where it is degraded. Under hypoxic conditions, no oxygen is available for proline hydroxylation. In this situation Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta, also termed ARNT. This complex then binds to a DNA region termed HRE (hypoxia responsive element). As a consequence target genes are transcribed. These genes are involved in the regulation of a multitude of processes, including erythropoesis, glycolysis and angiogenesis.
ulashishga – ishlanmani nusxalash, tarqatish va uzatish
remiks qilishga – ishni moslashtirishga
Quyidagi shartlar asosida:
atribut – Siz tegishli litsenziyaga havolani taqdim etishingiz va oʻzgartirishlar kiritilganligini koʻrsatishingiz kerak. Siz buni har qanday oqilona yoʻl bilan qilishingiz mumkin, lekin litsenziar Sizni yoki Sizning foydalanishingizni ma'qullashini taklif qiladigan tarzda emas.
bir xil ulashish – Agar Siz materialni remiks qilsangiz, oʻzgartirsangiz yoki unga asoslansangiz, oʻz hissalaringizni asl nusxadagi kabi bir xil yoki mos litsenziya ostida tarqatishingiz kerak.
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Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability