DTX1

DTX1
Identifikatorlar
Nomenklatura	DTX1, hDx-1, deltex 1, deltex E3 ubiquitin ligase 1, RNF140
Tashqi IDlar	OMIM: 602582 MGI: 1352744 HomoloGene: 74522 GeneCards: DTX1
Gen joylashuvi (odam)
Xr.	Chromosome 12 (human)
Oxir.	113,098,028 bp
Gen joylashuvi (sichqon)
Xr.	Chromosome 5 (mouse)
Oxir.	120,849,992 bp
RNK ekspressiyasi profili
	Top expressed in
	Taloq; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; nucleus accumbens; ; Brodmann area 9; ; Amigdala; ; ganglionic eminence; ; prefrontal cortex;
	Top expressed in
	entorhinal cortex; ; mesenteric lymph nodes; ; perirhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; Motor neyron; ; superior colliculus; ; cerebellar cortex; ; lumbar subsegment of spinal cord; ; Rostral migratory stream;
	More reference expression data
	More reference expression data
Gen ontologiyasi
Molecular function	SH3 domain binding; transcription coactivator activity; zinc ion binding; protein binding; ubiquitin protein ligase binding; metal ion binding; Notch binding; transferase activity;
Cellular component	Sitoplazma; Hujayra yadrosi; nucleoplasm; cytosol; nuclear body;
Biological process	Notch signaling pathway; cell surface receptor signaling pathway; glial cell differentiation; transcription by RNA polymerase II; regulation of Notch signaling pathway; negative regulation of T cell differentiation; negative regulation of neuron differentiation; protein ubiquitination; transcription, DNA-templated; cellular response to leukemia inhibitory factor; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Ortologiya
	1840
	14357
	ENSG00000135144
	ENSMUSG00000029603
	Q86Y01
	Q61010
	NM_004416
	NM_008052
	NP_004407
	NP_032078
	Vikimaʼlumotlar
koʻrish/tahrirlash (odam)	koʻrish/tahrirlash (sichqon)

Protein deltex-1 - bu odamlarda DTX1 geni tomonidan kodlangan oqsil^[5]^[6].

Xususiyati

Drosophilada olib borilgan tadqiqotlar, bu genni, tish signalizatsiya yoʻlining ijobiy regulyatorini kodlash sifatida aniqladi. Inson geni nomaʼlum funksiyali oqsilni kodlaydi. Lekin u asosiy spiral-loop-spiral transkripsiya omili faoliyatida rol oʻynashi mumkin^[6].

Oʻzaro taʼsirlari

DTX1 EP300 bilan oʻzaro aloqada boʻlishi koʻrsatilgan^[7].

Manbalar

↑ ^1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000135144 - Ensembl, May 2017
↑ ^2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000029603 - Ensembl, May 2017
↑ „Human PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ „Mouse PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ „Human deltex is a conserved regulator of Notch signalling“. Nature Genetics. 19-jild, № 1. 1998-yil may. 74–8-bet. doi:10.1038/ng0598-74. PMID 9590294. {{cite magazine}}: sana kiritilishi kerak boʻlgan parametrga berilgan qiymatni tekshirish lozim: |date= (yordam)
↑ ^6,0 ^6,1 „Entrez Gene: DTX1 deltex homolog 1 (Drosophila)“. Manba xatosi: Invalid <ref> tag; name "entrez" defined multiple times with different content
↑ „Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor“. The Journal of Biological Chemistry. 276-jild, № 48. 2001-yil noyabr. 45031–40-bet. doi:10.1074/jbc.M105245200. PMID 11564735. {{cite magazine}}: sana kiritilishi kerak boʻlgan parametrga berilgan qiymatni tekshirish lozim: |date= (yordam)

Qoʻshimcha oʻqish

[refGRCh38Ensembl-1] 1,0 ^1,1 ^1,2 GRCh38: Ensembl release 89: ENSG00000135144 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2,0 ^2,1 ^2,2 GRCm38: Ensembl release 89: ENSMUSG00000029603 - Ensembl, May 2017

[3] „Human PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] „Mouse PubMed Reference:“. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9590294-5] „Human deltex is a conserved regulator of Notch signalling“. Nature Genetics. 19-jild, № 1. 1998-yil may. 74–8-bet. doi:10.1038/ng0598-74. PMID 9590294. {{cite magazine}}: sana kiritilishi kerak boʻlgan parametrga berilgan qiymatni tekshirish lozim: |date= (yordam)

[entrez-6] 6,0 ^6,1 „Entrez Gene: DTX1 deltex homolog 1 (Drosophila)“. Manba xatosi: Invalid <ref> tag; name "entrez" defined multiple times with different content

[pmid11564735-7] „Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor“. The Journal of Biological Chemistry. 276-jild, № 48. 2001-yil noyabr. 45031–40-bet. doi:10.1074/jbc.M105245200. PMID 11564735. {{cite magazine}}: sana kiritilishi kerak boʻlgan parametrga berilgan qiymatni tekshirish lozim: |date= (yordam)

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