Estrogen retseptorlari

Estrogen retseptorlari ( ER ) hujayralar ichida joylashgan oqsillar guruhi. Ular estrogen garmoni ( 17b-estradiol ) tomonidan faollashtirilgan retseptorlardir . ^[1] ER ning ikkita sinfi mavjud: hujayra ichidagi retseptorlarning yadro retseptorlari oilasining a'zolari bo'lgan yadroviy estrogen retseptorlari ( ERa va ERb ) va membrana estrogen retseptorlari (mERs) ( GPER (GPR30), ER-X va G <sub id="mwGw">q</sub> -mER ), ular asosan G protein bilan bog'langan retseptorlari.

Estrogen tomonidan faollashtirilgandan so'ng, ER yadroga o'tishga va turli genlarning faoliyatini tartibga solish uchun DNK bilan bog'lanishga qodir (ya'ni bu DNKni bog'lovchi transkripsiya omili). Shu bilan birga, u DNK bilan bog'lanishdan mustaqil ravishda qo'shimcha funksiyalarga ega. ^[2]

Jinsiy steroid(garmon) uchun garmon retseptorlari sifatida ( steroid gormon retseptorlari ), ER'lar, androgen retseptorlari (AR) va progesteron retseptorlari(ayollarda ajralib chiqadigan garmon) (PR) jinsiy etilish va homiladorlikda muhim ahamiyatga ega.

Proteomika

Odatda a va b deb ataladigan estrogen retseptorlarining ikki xil shakli mavjud bo'lib, ularning har biri alohida gen tomonidan kodlangan (mos ravishda ESR1 va ESR2 ). Garmon bilan faollashtirilgan estrogen retseptorlari dimerlarni hosil qiladi va bu ikki shakl ko'plab hujayra turlarida birgalikda ifodalanganligi sababli, retseptorlar ERa (a) yoki ERb (b) homodimerlari yoki ERab (ab) heterodimerlarini hosil qilishi mumkin. ^[3] Estrogen retseptorlari alfa va beta muhim umumiy ketma-ketlik homologiyasini ko'rsatadi va ikkalasi ham A/B dan F gacha bo'lgan beshta domendan iborat (N-dan C-terminusgacha sanab o'tilgan; aminokislotalarning tartib raqamlari inson ERga tegishli).

↑ "International Union of Pharmacology. LXIV. Estrogen receptors". Pharmacological Reviews 58 (4): 773–81. Dec 2006. doi:10.1124/pr.58.4.8. PMID 17132854.
↑ "Integration of the extranuclear and nuclear actions of estrogen". Molecular Endocrinology 19 (8): 1951–9. Aug 2005. doi:10.1210/me.2004-0390. PMID 15705661. PMC 1249516. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1249516.
↑ "Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways". Molecular and Cellular Biology 24 (17): 7681–94. Sep 2004. doi:10.1128/MCB.24.17.7681-7694.2004. PMID 15314175. PMC 506997. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=506997.

[pmid17132854-1] "International Union of Pharmacology. LXIV. Estrogen receptors". Pharmacological Reviews 58 (4): 773–81. Dec 2006. doi:10.1124/pr.58.4.8. PMID 17132854.

[pmid15705661-2] "Integration of the extranuclear and nuclear actions of estrogen". Molecular Endocrinology 19 (8): 1951–9. Aug 2005. doi:10.1210/me.2004-0390. PMID 15705661. PMC 1249516. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1249516.

[pmid15314175-3] "Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways". Molecular and Cellular Biology 24 (17): 7681–94. Sep 2004. doi:10.1128/MCB.24.17.7681-7694.2004. PMID 15314175. PMC 506997. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=506997.

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