Ftor-18

Andoza:Infobox isotope

Ftor-18 ( ¹⁸F) pozitronlarning manbai bo'lgan ftor radioizotopidir . Massasi 18,0009380(6) , yarim yemirilish davri 109,771(20) minut. U 96% pozitron emissiyasi asosida parchalanadi va u o'zida 4% elektroni ushlaydi . Parchalanishning ikkala holida ham barqaror kislorod-18 hosil qiladi.

Tabiiy hodisa

¹⁸F → ¹⁸O + e⁺ + ν_e.

Sintez

Radiofarmatsevtika sanoatida ftor-18 siklotron yoki chiziqli zarracha tezlatgich yordamida nishonni bombardimon qilish uchun tayyorlanadi, odatda tabiiy yoki yuqori energiyali protonlar (odatda ~18 MeV ) bilan boyitilgan [ ¹⁸O] suvdan ^[1] . Ishlab chiqarilgan ftor [ ¹⁸F] ftoridning suvli eritmasi shaklida bo'lib, keyinchalik u turli radiofarmatsevtikalarning tez kimyoviy sintezida ishlatiladi.

Tarix

Ftor-18 ning birinchi sintezi va xossalari haqidagi hisobot 1937 yilda Ernest O. Lourensning siklotron laboratoriyalarida ²⁰ Ne(d,a) ¹⁸F yadro reaksiyasi natijasida ishlab chiqarilgan Artur X.

Kimyo

Ftor-18 ko'pincha o'xshash sterik va elektrostatik xususiyatlar tufayli radiotraserning asosiy molekulasidagi gidroksil guruhi (–OH) bilan almashtiriladi.

Ilovalar

Ftor-18 pozitron emissiya tomografiyasida (PET) qo'llaniladigan radiyonuklid periparatlardan biri bo'lib , 1960-yildan tibbiyotda qo'llanilmoqda.^[2] Ftor-18ning ahamiyatliligi shundaki yarimparchalanish davrining qisqaligi va parchalanish vaqtida pozitronlarning chiqishi bilan bog'liq. Ftor-18 dan tibbiyotda foydalanish: miya va yurakni tasvirlash uchun pozitron emissiya tomografiyasida (PET); qalqonsimon bezni tasvirlash; tasvir suyaklari uchun radiotraser sifatida, tananing boshqa joylaridan metastazlangan saratonlarni qidirishda va ichki o'smalarni davolashda radiatsiya terapiyasida.

Tracerlar orasida skeletni tasvirlash uchun foydali bo'lishi mumkin bo'lgan natriy ftorid kiradi, chunki u suyakning yuqori va tez so'rilishini va juda tez qon klirensini ko'rsatadi, bu esa qisqa vaqt ichida suyakning fonga nisbati yuqori bo'lishiga olib keladi ^[3] va florodeoksiglyukoza (FDG), bu yerda ¹⁸F gidroksilni almashtiradi. Yangi dioksaborolan kimyosi antikorlarni radioaktiv ftorid ( ¹⁸F) bilan belgilash imkonini beradi, bu esa saraton kasalligini pozitron emissiya tomografiyasini (PET) ko'rish imkonini beradi.^[4] Insoniy, Genetik, Pozitron chiqaradigan va F- lyuminestsent (HD-GPF) reportyor tizimi inson oqsili, PSMA va immunogen bo'lmagan va pozitron chiqaradigan ( ¹⁸F) va floresan kichik molekuladan foydalanadi. butun sichqonchada genom o'zgartirilgan hujayralarni, masalan, saraton, CRISPR/Cas9 yoki CAR T -hujayralarini ikki tomonlama PET va floresan tasvirlash uchun.^[5]^[6]

Ma'lumotnomalar

↑ Fowler J. S. and Wolf A. P. (1982). The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.
↑ Blau, Monte; Ganatra, Ramanik; Bender, Merrill A. (January 1972). „18F-fluoride for bone imaging“. Seminars in Nuclear Medicine. 2-jild, № 1. 31–37-bet. doi:10.1016/S0001-2998(72)80005-9. PMID 5059349.
↑ Ordonez, A. A.; DeMarco, V. P.; Klunk, M. H.; Pokkali, S.; Jain, S.K. (October 2015). „Imaging Chronic Tuberculous Lesions Using Sodium [18F]Fluoride Positron Emission Tomography in Mice“. Molecular Imaging and Biology. 17-jild, № 5. 609–614-bet. doi:10.1007/s11307-015-0836-6. PMC 4561601. PMID 25750032.
↑ Rodriguez, Erik A.; Wang, Ye; Crisp, Jessica L.; Vera, David R.; Tsien, Roger Y.; Ting, Richard (2016-04-27). „New Dioxaborolane Chemistry Enables [18F]-Positron-Emitting, Fluorescent [18F]-Multimodality Biomolecule Generation from the Solid Phase“. Bioconjugate Chemistry (inglizcha). 27-jild, № 5. 1390–1399-bet. doi:10.1021/acs.bioconjchem.6b00164. PMC 4916912. PMID 27064381.
↑ Guo, Hua; Harikrishna, Kommidi; Vedvyas, Yogindra; McCloskey, Jaclyn E; Zhang, Weiqi; Chen, Nandi; Nurili, Fuad; Wu, Amy P; Sayman, Haluk B. (2019-05-23). „A fluorescent, [ 18 F]-positron-emitting agent for imaging PMSA allows genetic reporting in adoptively-transferred, genetically-modified cells“. ACS Chemical Biology (inglizcha). 14-jild, № 7. 1449–1459-bet. doi:10.1021/acschembio.9b00160. ISSN 1554-8929. PMC 6775626. PMID 31120734.
↑ Aras, Omer; Demirdag, Cetin; Kommidi, Harikrishna; Guo, Hua; Pavlova, Ina; Aygun, Aslan; Karayel, Emre; Pehlivanoglu, Hüseyin; Yeyin, Nami (March 2021). „Small Molecule, Multimodal [18F]-PET and Fluorescence Imaging Agent Targeting Prostate Specific Membrane Antigen: First-in-Human Study“. Clinical Genitourinary Cancer (inglizcha). 19-jild, № 5. 405–416-bet. doi:10.1016/j.clgc.2021.03.011. PMC 8449790. PMID 33879400.

[1] Fowler J. S. and Wolf A. P. (1982). The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.

[2] Blau, Monte; Ganatra, Ramanik; Bender, Merrill A. (January 1972). „18F-fluoride for bone imaging“. Seminars in Nuclear Medicine. 2-jild, № 1. 31–37-bet. doi:10.1016/S0001-2998(72)80005-9. PMID 5059349.

[3] Ordonez, A. A.; DeMarco, V. P.; Klunk, M. H.; Pokkali, S.; Jain, S.K. (October 2015). „Imaging Chronic Tuberculous Lesions Using Sodium [18F]Fluoride Positron Emission Tomography in Mice“. Molecular Imaging and Biology. 17-jild, № 5. 609–614-bet. doi:10.1007/s11307-015-0836-6. PMC 4561601. PMID 25750032.

[4] Rodriguez, Erik A.; Wang, Ye; Crisp, Jessica L.; Vera, David R.; Tsien, Roger Y.; Ting, Richard (2016-04-27). „New Dioxaborolane Chemistry Enables [18F]-Positron-Emitting, Fluorescent [18F]-Multimodality Biomolecule Generation from the Solid Phase“. Bioconjugate Chemistry (inglizcha). 27-jild, № 5. 1390–1399-bet. doi:10.1021/acs.bioconjchem.6b00164. PMC 4916912. PMID 27064381.

[5] Guo, Hua; Harikrishna, Kommidi; Vedvyas, Yogindra; McCloskey, Jaclyn E; Zhang, Weiqi; Chen, Nandi; Nurili, Fuad; Wu, Amy P; Sayman, Haluk B. (2019-05-23). „A fluorescent, [ 18 F]-positron-emitting agent for imaging PMSA allows genetic reporting in adoptively-transferred, genetically-modified cells“. ACS Chemical Biology (inglizcha). 14-jild, № 7. 1449–1459-bet. doi:10.1021/acschembio.9b00160. ISSN 1554-8929. PMC 6775626. PMID 31120734.

[6] Aras, Omer; Demirdag, Cetin; Kommidi, Harikrishna; Guo, Hua; Pavlova, Ina; Aygun, Aslan; Karayel, Emre; Pehlivanoglu, Hüseyin; Yeyin, Nami (March 2021). „Small Molecule, Multimodal [18F]-PET and Fluorescence Imaging Agent Targeting Prostate Specific Membrane Antigen: First-in-Human Study“. Clinical Genitourinary Cancer (inglizcha). 19-jild, № 5. 405–416-bet. doi:10.1016/j.clgc.2021.03.011. PMC 8449790. PMID 33879400.

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